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Spontaneous Cholangiofibrosis in a Wistar Rat

descriptionPublicationkeyboard_double_arrow_right Article 15 Apr 2019Publisher:SAGE PublicationsJournal:Toxicologic Pathology, volume 47, pages 556-560 (issn: 0192-6233, eissn: 1533-1601,

Authors: Tao Chen; Ke Chen; Shaung Qiu; Peter C. Mann;

doi: 10.1177/0192623319842549

pmid: 30987525

Spontaneous Cholangiofibrosis in a Wistar Rat

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Abstract

In a 2-year carcinogenicity study, we identified a spontaneous cholangiofibrosis in a control male Wistar rat. This lesion has long been considered as a compound-related change, with no spontaneous cases reported in the Wistar rat. In addition to routine hematoxylin and eosin stains evaluation, we applied Masson’s trichrome staining, Alcian blue-periodic acid–Schiff staining, and OV-6 immunohistochemistry staining. The special staining demonstrated the fibrous component in the interstitium and intestinal metaplasia of the epithelium (presence of goblet cells), while the positive anti-OV-6 reaction indicated the bile duct origin of the epithelium. These results help to confirm the diagnosis of cholangiofibrosis in this case. We report this rare case to alert pathologists that spontaneous cholangiofibrosis does occur in Wistar rats.

Related Organizations

Experimental Pathology Laboratories
United States

Keywords

Male, Metaplasia, Biliary Tract Diseases, Fibrosis, Immunohistochemistry, Epithelium, Abortion, Spontaneous, Dogs, Microscopy, Fluorescence, Animals, Bile Ducts, Dog Diseases, Rats, Wistar

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