Clinical correlates of body weight changes in schizophrenia

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1994 English Publisher:American Psychiatric Association PublishingJournal:The Journal of Neuropsychiatry and Clinical Neurosciences, volume 6, pages 187-188 (issn: 0895-0172, eissn: 1545-7222,

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Authors: W B, Lawson; C N, Karson;

doi: 10.1176/jnp.6.2.187

pmid: 8044044

Clinical correlates of body weight changes in schizophrenia

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Abstract

Body weight was examined in chronic schizophrenic patients. Underweight medicated patients had normal ventricular brain ratios (VBRs) on CT. Overweight patients had both normal and abnormal VBRs. Weight decreased during neuroleptic withdrawal; caloric intake and weight increased when neuroleptics were reinstituted. Weight gain on neuroleptics correlated with symptom improvement independent of VBR or gender. Weight changes and psychosis in schizophrenia may be mediated by similar neurochemical systems.

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Keywords

Adult, Male, Psychiatric Status Rating Scales, Brain, Weight Gain, Cerebral Ventricles, Substance Withdrawal Syndrome, Schizophrenia, Haloperidol, Humans, Female, Schizophrenic Psychology, Atrophy, Energy Intake, Tomography, X-Ray Computed

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