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Tricyclic antidepressants in obsessive-compulsive disorder: antiobsessional or antidepressant agents? II

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1985Publisher:American Psychiatric Association PublishingJournal:American Journal of Psychiatry, volume 142, pages 572-576 (issn: 0002-953X, eissn: 1535-7228,

Authors: Matig Mavissakalian; Samuel M. Turner; Larry Michelson; Rolf G. Jacob;

doi: 10.1176/ajp.142.5.572

pmid: 3885761

Tricyclic antidepressants in obsessive-compulsive disorder: antiobsessional or antidepressant agents? II

- Summary
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Abstract

The authors explored the relationship between the antiobsessional and antidepressant effects of tricyclic drugs in primary obsessive-compulsive disorders. Study 1 consisted of a controlled 12-week trial with clomipramine (N = 7) and placebo (N = 5); study 2 analyzed the pooled data from 15 patients uniformly selected and treated with either clomipramine or imipramine. Although the antiobsessional and antidepressant effects of the drugs covaried, their antidepressant action was not a prerequisite for their antiobsessional effect. The findings suggest that clomipramine and probably imipramine possess specific antiobsessive effects that are at least partially independent of their antidepressant effects.

Keywords

Adult, Male, Psychiatric Status Rating Scales, Clinical Trials as Topic, Depressive Disorder, Imipramine, Obsessive-Compulsive Disorder, Middle Aged, Placebos, Random Allocation, Double-Blind Method, Clomipramine, Humans, Female

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	150
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%