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The Journal of Clinical Investigation
Article . 2005 . Peer-reviewed
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The Journal of Clinical Investigation
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The Journal of Clinical Investigation
Article . 2006
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The Journal of Clinical Investigation
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Thrombus formation in vivo

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2005 English Publisher:American Society for Clinical InvestigationJournal:Journal of Clinical Investigation, volume 115, pages 3,355-3,362 (issn: 0021-9738, Copyright policy )
Authors: Bruce Furie; Barbara C. Furie;

doi: 10.1172/jci26987

pmid: 16322780

pmc: PMC1297262

Thrombus formation in vivo

Abstract

To examine thrombus formation in a living mouse, new technologies involving intravital videomicroscopy have been applied to the analysis of vascular windows to directly visualize arterioles and venules. After vessel wall injury in the microcirculation, thrombus development can be imaged in real time. These systems have been used to explore the role of platelets, blood coagulation proteins, endothelium, and the vessel wall during thrombus formation. The study of biochemistry and cell biology in a living animal offers new understanding of physiology and pathology in complex biologic systems.

Related Organizations
Keywords

Blood Platelets, Blood Cells, Microscopy, Video, Microcirculation, Thrombosis, Platelet Activation, Models, Biological, Hematopoiesis, Thromboplastin, Arterioles, Mice, Platelet Adhesiveness, Blood Circulation, Animals, Humans, Calcium, Blood Coagulation

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 398
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
398
Top 1%
Top 1%
Top 1%
gold