Heparan sulfate: Antithrombotic or not?
Copyright policy )Heparan sulfate: Antithrombotic or not?
With their studies in 3-OST-1 knockout mice, HajMohammadi and colleagues (15) have advanced our understanding of the pathways that regulate thrombin. Antithrombin is critical for thrombin regulation because even partial deficiency is associated with thrombosis. In contrast, complete deficiency of heparan sulfate activity is necessary to provoke thrombosis. These findings suggest that small amounts of residual heparan sulfate activity are sufficient to catalyze antithrombin or that other vessel wall glycosaminoglycans can compensate for all but complete lack of heparan sulfate activity.
- University of Massachusetts System United States
- University of Massachusetts Amherst United States
Mice, Knockout, Fibrin, Mice, Fibrinolytic Agents, Gene Expression Regulation, Thrombin, Animals, Fibrinogen, Mice, Transgenic, Heparitin Sulfate, Models, Biological
Mice, Knockout, Fibrin, Mice, Fibrinolytic Agents, Gene Expression Regulation, Thrombin, Animals, Fibrinogen, Mice, Transgenic, Heparitin Sulfate, Models, Biological
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