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The Journal of Clinical Investigation
Article . 1974 . Peer-reviewed
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The Journal of Clinical Investigation
Article
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The Journal of Clinical Investigation
Article . 1974
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The Journal of Clinical Investigation
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Hemoglobin San Diego (β109 (G11) Val→Met) CRYSTAL STRUCTURE OF THE DEOXY FORM

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1974 English Publisher:American Society for Clinical InvestigationJournal:Journal of Clinical Investigation, volume 53, pages 329-333 (issn: 0021-9738, Copyright policy )
Authors: N. Leigh Anderson;

doi: 10.1172/jci107554

pmid: 4808645

pmc: PMC301468

Hemoglobin San Diego (β109 (G11) Val→Met) CRYSTAL STRUCTURE OF THE DEOXY FORM

Abstract

The three-dimensional structure of deoxyhemoglobin San Diego has been solved to 3.5 A resolution using mixed crystals of the variant hemoglobin and hemoglobin A. The site of the amino acid replacement can be clearly located in the difference electron density map and is consistent with the chemical result (beta109 Val-->Met) discussed in the preceding paper. The abnormally high oxygen affinity and impaired cooperativity appear to result from perturbations of the alpha(1)beta(1)-subunit interface.

Keywords

Models, Structural, Methionine, Hemoglobins, Abnormal, Mutation, Molecular Conformation, Valine, Crystallization

  • BIP!
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Average
Top 10%
Average
gold