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A Prototype Antifungal Contact Lens

Name: A Prototype Antifungal Contact Lens
Keywords: Antifungal Agents, outbreak, ganciclovir, temperature, Biocompatible Materials, Equipment Design, Contact Lenses, Hydrophilic, Spectrum Analysis, Raman, susceptibility, drug-delivery

descriptionPublicationkeyboard_double_arrow_right Article 09 Aug 2011Embargo end date: 01 Aug 2025 English Publisher:Association for Research in Vision and Ophthalmology (ARVO)Journal:Investigative Opthalmology & Visual Science, volume 52, page 6,286 (issn: 1552-5783,

Copyright policy )Publicly fundedFunded by:NSERC | unidentified, NIH | Drug Eluting Contact Lens..., NIH | Prolonged Duration Local ...

Authors: Daniel S. Kohane; Joseph B. Ciolino; Ashley N. Mobbs; Naomi G. Iwata; Todd Hoare; Sarah P. Hudson; Gerald R. Fink;

doi: 10.1167/iovs.10-6935 , 10.34961/4605

pmid: 21527380

pmc: PMC3176015

A Prototype Antifungal Contact Lens

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Abstract

PURPOSE. To design a contact lens to treat and prevent fungal ocular infections.METHODS. Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37 degrees C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.RESULTS. Econazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens.CONCLUSIONS. An econazole-eluting contact lens could be used as a treatment for fungal ocular infections. (Invest Ophthalmol Vis Sci. 2011;52:6286-6291) DOI:10.1167/iovs.10-6935

peer-reviewed

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Keywords

Antifungal Agents, outbreak, ganciclovir, temperature, Biocompatible Materials, Equipment Design, Contact Lenses, Hydrophilic, Spectrum Analysis, Raman, susceptibility, drug-delivery, Drug Delivery Systems, Polylactic Acid-Polyglycolic Acid Copolymer, Candida albicans, Microscopy, Electron, Scanning, fungal keratitis, Lactic Acid, Desiccation, Econazole, Corneal Ulcer, Polyglycolic Acid, Polyhydroxyethyl Methacrylate, management, fusarium

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	93
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%