ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin
Copyright policy )ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin
ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP. Although Ca2+ signalling is a critical regulator of early development, little is known of the role of ADP-ribosyl cyclases during embryogenesis. Here we analyze the expression, activity and function of ADP-ribosyl cyclases in the embryo of the sea urchin - a key organism for study of both Ca2+ signalling and embryonic development. ADP-ribosyl cyclase isoforms (SpARC1-4) showed unique changes in expression during early development. These changes were associated with an increase in the ratio of cADPR:NAADP production. Over-expression of SpARC4 (a preferential cyclase) disrupted gastrulation. Our data highlight the importance of ADP-ribosyl cyclases during embryogenesis.
- University of California, San Francisco United States
- University College London United Kingdom
- University of California, San Diego United States
- University of California, San Diego United States
- University of California System United States
570, EARLY DEVELOPMENT, NAADP, 610, early development, ADP-ribosyl cyclase, ADP-RIBOSYL CYCLASE, cyclic ADP-ribose, GASTRULATION, gastrulation, CYCLIC ADP-RIBOSE
570, EARLY DEVELOPMENT, NAADP, 610, early development, ADP-ribosyl cyclase, ADP-RIBOSYL CYCLASE, cyclic ADP-ribose, GASTRULATION, gastrulation, CYCLIC ADP-RIBOSE
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