Two new monotypic genera of Gyponini from South America are proposed, described and illustrated. Caetana gen. nov., from Brazil and Ecuador, differs from other genera of the tribe by the scutellum strongly inflated; forewing expanded apically and hind wing with long r-m and m-cu. Insolitana gen. nov., from Peru, differs from other genera by the presence of a pair of longitudinal carinae on crown; crown, noto, and clavus punctuated; male sternite VIII (= pregenital sternite) fully covering the subgenital plates; and pygofer with internal dorsoapical process.