descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2000 English Publisher:Walter de Gruyter GmbHJournal:Haematologia, volume 30, pages 289-302 (issn: 0017-6559, eissn: 1568-5594,

Authors: Mladen Petrovečki; Igor Aurer; Milivoj Boranić; Branka Golubić-Ćepulić; Mirna Sučić; Silvana Stanović Janda; Boris Labar;

doi: 10.1163/156855900300109530

pmid: 11204028

Effects of a membrane-metallopeptidase blocking agent thiorphan in long-term cultures of human bone marrow

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Abstract

Thiorphan [(DL-3-mercapto-2-benzylpropanoyl)-glycine], a drug blocking the activity of membrane metalloendopeptidase EC 3.4.24.11 (CD10, CALLA), was added to long-term cultures of human bone marrow. Progression of the cultures was assessed by cell counts, cytology and clonogenic (GM-CFU) ability of the non-adherent cells in the supernatant and by morphology of the adherent stromal layer. A stimulatory effect on hematopoiesis was noted.

Related Organizations

Ruđer Bošković Institute
Croatia

Keywords

Thiorphan, GM-CFU, EC 3.4.24.11) thiorphan, Bone Marrow Cells, Cell Differentiation, Membrane metalloendopeptidase (CD10, macrophages, ovarian cancer, Long-term bone marrow culture (LTBMC), Humans, Neprilysin, Protease Inhibitors, Long-term bone marrow culture (LTBMC) ; GM-CFU ; macrophages ; Membrane metalloendopeptidase (CD10 ; EC 3.4.24.11) thiorphan ; ovarian cancer, Cell Division, Cells, Cultured

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