See related article, pp 1041–1046 Attention must be paid to the article by Roush et al1 in this edition of Hypertension . The authors use robust statistics to compare the antihypertensive potency and adverse effects of hydrochlorothiazide versus indapamide in the 10 publications that could be identified, wherein the 2 drugs were compared head-to-head in trials lasting ≥4 weeks. Indapamide, used as 2.5 mg tablets in all but 1 trial, provided a 54% greater reduction in systolic blood pressure, that is, −5.1 mm Hg (confidence interval, −8.7 to −1.6) than seen with hydrochlorothiazide in doses from 12.5 to 50 mg/d. The relative doses were greater for hydrochlorothiazide in 5 trials and equivalent in 3 trials. The blood pressures were measured by office sphygmomanometry in all these trials but reference is given to studies using 24-hour ambulatory measurements, which showed ≥24-hour duration of diuretic and antihypertensive efficacy with the immediate formulation of indapamide and ≥32-hour duration with the sustained formulation (which was used in only one of the trials).2 Roush et al1 refer to multiple additional vasodilatory actions described in the literature in support of the greater reduction of blood pressure …