On the Origin of Urinary Angiotensin II
Copyright policy )On the Origin of Urinary Angiotensin II
To the Editor: With great interest we read the publication by Shao et al,1 who propose that angiotensin (Ang) II type 1 (AT1) receptor stimulation in the kidney results in urinary Ang II excretion. The authors have used an elegant approach, infusing rats with Val5-Ang II to allow a clear distinction from endogenous Ile5-Ang II, here denoted as Ang II. Val5-Ang II is believed to have the same properties as Ang II. We have followed a similar approach and infused 125I-labeled Ang II in pigs to distinguish it from endogenous Ang II.2 In these studies, 125I-Ang II accumulation in the kidney, largely, …
- Erasmus University Rotterdam Netherlands
- Erasmus University Medical Center Netherlands
Swine, Angiotensin II, Biphenyl Compounds, Tetrazoles, Blood Pressure, Kidney, Receptor, Angiotensin, Type 1, Rats, Animals, Benzimidazoles, Angiotensin II Type 1 Receptor Blockers, EMC COEUR-09
Swine, Angiotensin II, Biphenyl Compounds, Tetrazoles, Blood Pressure, Kidney, Receptor, Angiotensin, Type 1, Rats, Animals, Benzimidazoles, Angiotensin II Type 1 Receptor Blockers, EMC COEUR-09
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