A 75-year-old man with hyperlipidemia was admitted with substernal chest tightness associated with an elevated cardiac-specific troponin. He had experienced symptoms of an upper respiratory tract infection with fever, cough, and decreased oral intake over the previous 2 weeks. He presented ≈4 hours after symptom onset with an initial troponin-T concentration of 0.29 ng/mL, eventually peaking at 0.31 ng/mL before downtrending. The ECG showed T-wave flattening in aVL with no previous ECG for comparison. Appropriate medical therapy for non–ST-elevation myocardial infarction was initiated, and the patient was taken to the cardiac catheterization laboratory. Coronary angiography was performed from the right radial artery approach. There were no significant lesions in the right coronary or left circumflex arteries. There was a 40% lesion in the midportion of the left anterior descending artery associated with myocardial bridging (Figure 1 and Movie I in the online-only Data Supplement), which became more prominent with the intracoronary administration of 200 μg of nitroglycerin. A coronary pressure wire (RADI Medical Systems, Uppsala, Sweden) was introduced across the segment of myocardial bridging. The distal-to-proximal pressure ratio at baseline was 0.86, and the fractional flow reserve (FFR) obtained after the intravenous administration of adenosine at 180 μg·kg–1·min–1 was 0.76 (Figure 2 …