Vascular Endothelial Growth Factor
Copyright policy )Vascular Endothelial Growth Factor
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
- GENENTECH INC United States
Vascular Endothelial Growth Factor A, Guinea Pigs, Molecular Sequence Data, Mice, Nude, Neovascularization, Physiologic, Angiogenesis Inhibitors, Endothelial Growth Factors, Eye, History, 21st Century, Mice, Neoplasms, Animals, Humans, Amino Acid Sequence, Growth Substances, Mice, Knockout, Lymphokines, Neovascularization, Pathologic, Receptor Protein-Tyrosine Kinases, Endothelial Cells, History, 20th Century, Rats, Alternative Splicing, Receptors, Vascular Endothelial Growth Factor, Gene Expression Regulation, Endothelium, Vascular, Signal Transduction
Vascular Endothelial Growth Factor A, Guinea Pigs, Molecular Sequence Data, Mice, Nude, Neovascularization, Physiologic, Angiogenesis Inhibitors, Endothelial Growth Factors, Eye, History, 21st Century, Mice, Neoplasms, Animals, Humans, Amino Acid Sequence, Growth Substances, Mice, Knockout, Lymphokines, Neovascularization, Pathologic, Receptor Protein-Tyrosine Kinases, Endothelial Cells, History, 20th Century, Rats, Alternative Splicing, Receptors, Vascular Endothelial Growth Factor, Gene Expression Regulation, Endothelium, Vascular, Signal Transduction
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