Three factors dominate the calculation of real estate value: location, location, and location. As I enter the second half of my editorship of Circulation Research , my reflections pinpoint translation, translation, and translation as the three critical factors dominating the future of our journal. This reflection has its roots in personal ruminations about the field of clinical cardiology and how it has evolved and is evolving today. Cardiology now finds itself in a defining epochal transition. We are on the threshold of a new Golden Age. Two Golden Ages have preceded that which we are just entering (see Table). In the 1970s and earlier, we experienced the Classical Age. This era was, necessarily, largely descriptive and observational; diseases were classified and codified, taking advantage of newly elucidated principles of fundamental hemodynamics and …