The problem of the relationship between hypertension and coronary occlusion has been re-examined. Using newly established limits of hypertension, 600 consecutive private patients with coronary occlusion—500 men and 100 women—all under 65 years of age, were studied. Hypertension did not appear to be a factor in producing coronary disease and occlusion among men, but was a definite factor in its causation among women. The possible relation of the serum cholesterol, the S f 12-20 lipoprotein fraction, and the sex hormones to atherosclerosis and hypertension is discussed.