The development of artificial pacemakers for the electrical control of the cardiac rhythm has greatly enhanced the physician's ability to treat cardiac dysrhythmias. Pacemakers have been useful in treating Stokes-Adams syndrome and symptomatic bradyeardias; they have helped control the occurrence of tachyarrhythmias and have played an important role in the management of arrhythmias accompanying myocardial infarctions. With their more frequent use, pacemakers have contributed to our knowledge of underlying conduction and natural pacemaker disorders. As new indications for artificial pacemaking have been elucidated, more complex pulse generators have been developed, and newer technics found for their insertion. In spite of recent development the pulse generators in general use have a limited useful lifetime. This paper reviews the indications for pacemaker insertion that are commonly employed. In addition, an approach to the problem of pulse generator replacement is presented.