Introduction : tick borne infections are caused by a variety of pathogens including bacteria viruses and protozoa that are transmitted through a tick bite. Rickettsioses are the most common vector borne diseases. They are considered as emerging and re-emerging infections. The diagnosis of Rickettsial infections remains challenging because of polymorphic and non-specific clinical presentations. On another hand, Rickettsia are intracellular bacteria, their isolation is difficult and limited to only reference laboratories.