A 32 year old man, right-handed soldier, was admitted to Emergency Department two hours after undergoing right wrist injury following a 2 meter fall onto the hand, in hyperextension. Clinical examination revealed a deformity of the wrist with an obvious open lunate enucleation (A). The neurovascular status was intact. Standard radiograph of the wrist demonstrated a completely enucleated lunate, associated with scaphoid and radial styloid fracture (B). Computed tomography (CT) scan confirmed diagnosis of trans-radial styloid, trans-scaphoid, perilunate dislocation (C and D). The lunate enucleation was treated by open reduction through a volar approach and internal fixation of associated injuries. Wrist reduction was maintained using K-wires placed through the scapholunate and scaphocapitate. The material was removed after 3 months. The control during one year postoperatively, there was no evidence of complications. The patient had a comfortable range of motion in his right wrist.Pan African Medical Journal 2015; 21