Chronic urticaria is a dermatological condition characterized by the appearance of wheals or angioedema longer than 6 weeks. It could cause serious complications such as laryngeal edema, vasculitis, and diarrhea. However, the pathologic changes of the ocular fundus caused by chronic urticaria are rarely reported. In this study, we described the pathologic changes of ocular fundus in a patient with history of chronic urticaria and central serous chorioretinopathy. A 28-year-old female was presented with blurred vision and distorted images in her right eye for 6 days. The patient was diagnosed with choroidal neovascularization. She received an intravitreal injection of conbercept (0.5 mg/eye/time) monthly. Finally, no abnormality was found in her ocular examination after 4 months of first injection. In conclusion, chronic urticaria could cause central serous chorioretinopathy, leading to choroidal neovascularization. Intravitreal conbercept injection showed an excellent local therapeutic efficacy for this eye condition.