Glucose-6-Phosphate Dehydrogenase Deficiency and Blood Transfusion
Copyright policy )Glucose-6-Phosphate Dehydrogenase Deficiency and Blood Transfusion
Abstract.Seven White American male blood donors with Italian surnames were found to have red cell glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficiency among 1,285 with Greek or Italian surnames screened. Five different genetic variants were found: G‐6‐PDs Mediterranean (2), ‘Athens‐like’ (2), San Juan, Columbus and ‘Canton‐like’. Clinical evaluation of 23 patients who received 24 units of G‐6‐PD‐deficient blood (G‐6‐PD A‐) failed to reveal any deleterious effects. Screening of Black donors for G‐6‐PD deficiency is believed unnecessary; further data are needed before a recommendation can be made concerning screening for non‐Black donors.
- University of Connecticut United States
- Palmetto Health Richland United States
- Georgetown University United States
Male, Reticulocytes, Black People, Blood Donors, Glucosephosphate Dehydrogenase, Hemolysis, White People, Black or African American, Connecticut, Glucosephosphate Dehydrogenase Deficiency, Italy, District of Columbia, Humans, Blood Transfusion
Male, Reticulocytes, Black People, Blood Donors, Glucosephosphate Dehydrogenase, Hemolysis, White People, Black or African American, Connecticut, Glucosephosphate Dehydrogenase Deficiency, Italy, District of Columbia, Humans, Blood Transfusion
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