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A Human Monoclonal Antibody to rh^G

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1986 English Publisher:WileyJournal:Vox Sanguinis, volume 50, pages 160-163 (issn: 0042-9007, eissn: 1423-0410,

Authors: Susan Perkins; F. Carl Grumet; Linda Winn; Steven K. H. Foung; Judy Blunt;

doi: 10.1159/000461416 , 10.1111/j.1423-0410.1986.tb04870.x

pmid: 2424176

A Human Monoclonal Antibody to rh^G

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Abstract

Abstract. Hybridomas secreting a human monoclonal IgG1 antibody against a variant of the rhG antigen were produced from B lymphocytes of an Rh‐negative donor with serum antibodies to D and C antigens. The antibody reacts by indirect hemagglutination with nearly all C‐ or D‐positive cells, confirming the strong association in the expression of G with D or C antigens. The lack of antibody reactivity to C‐negative Du cells suggests a particular epitope on the D complex associated with the G antigen.

Related Organizations

Stanford University
United States
Stanford Medicine
United States

Keywords

B-Lymphocytes, Epitopes, Hemagglutinins, Hybridomas, Antibody Specificity, Immunoglobulin G, Antibodies, Monoclonal, Humans

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	16
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%