
<b><i>Background and Purpose:</i></b> Non-vitamin K anticoagulants (NOAC) such as dabigatran have become important therapeutic options for the prevention of stroke. Until recently, there were only nonspecific agents to reverse their anticoagulant effects in a case of emergency. Idarucizumab, an antibody fragment targeting dabigatran, is the first specific antidote for a NOAC to be approved, but real-world experience is limited. <b><i>Methods:</i></b> We report two cases of patients on dabigatran with acute intracerebral hemorrhage who received idarucizumab. <b><i>Results:</i></b> In both cases, idarucizumab promptly reversed the anticoagulant effect of dabigatran and there was no hematoma expansion in follow-up imaging. <b><i>Conclusions:</i></b> In addition to clinical and preclinical studies, our cases add to the experience regarding the safety and efficacy of idarucizumab. They show that idarucizumab may be an important safety option for patients on dabigatran in emergency situations.
Stroke, Antidote, Idarucizumab, Anticoagulant, Case Report, Neurology. Diseases of the nervous system, Intracerebral hemorrhage, RC346-429, Dabigatran
Stroke, Antidote, Idarucizumab, Anticoagulant, Case Report, Neurology. Diseases of the nervous system, Intracerebral hemorrhage, RC346-429, Dabigatran
| citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 17 | |
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| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
