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Case Reports in Neurology
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Idarucizumab as Antidote to Intracerebral Hemorrhage under Treatment with Dabigatran

Authors: Philipp Eisele; Kristina Szabo; Christoph C. Eschenfelder; Valentin Held;

Idarucizumab as Antidote to Intracerebral Hemorrhage under Treatment with Dabigatran

Abstract

<b><i>Background and Purpose:</i></b> Non-vitamin K anticoagulants (NOAC) such as dabigatran have become important therapeutic options for the prevention of stroke. Until recently, there were only nonspecific agents to reverse their anticoagulant effects in a case of emergency. Idarucizumab, an antibody fragment targeting dabigatran, is the first specific antidote for a NOAC to be approved, but real-world experience is limited. <b><i>Methods:</i></b> We report two cases of patients on dabigatran with acute intracerebral hemorrhage who received idarucizumab. <b><i>Results:</i></b> In both cases, idarucizumab promptly reversed the anticoagulant effect of dabigatran and there was no hematoma expansion in follow-up imaging. <b><i>Conclusions:</i></b> In addition to clinical and preclinical studies, our cases add to the experience regarding the safety and efficacy of idarucizumab. They show that idarucizumab may be an important safety option for patients on dabigatran in emergency situations.

Keywords

Stroke, Antidote, Idarucizumab, Anticoagulant, Case Report, Neurology. Diseases of the nervous system, Intracerebral hemorrhage, RC346-429, Dabigatran

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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
17
Average
Top 10%
Top 10%
Green
gold