Sphingosine 1-Phosphate in Renal Diseases
Copyright policy )Sphingosine 1-Phosphate in Renal Diseases
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.
- University of Bern
- University of Bern
- Institute of Pharmacology Poland
- University of Bern Switzerland
- Institute of Pharmacology Czech Republic
Physiology, Kidney Glomerulus, 610, Ischemia-reperfusion injury, 610 Medicine & health, Diabetic nephropathy, QD415-436, Biochemistry, Glomerulonephritis, Sphingosine, QP1-981, Animals, Humans, Sphingosine Kinase, ddc:610, Wilms tumor, Kidney disease, Disease Models, Animal, Phosphotransferases (Alcohol Group Acceptor), Receptors, Lysosphingolipid, Kidney Tubules, Sphingosine 1-phosphate, Kidney Diseases, Lysophospholipids, ddc: ddc:610
Physiology, Kidney Glomerulus, 610, Ischemia-reperfusion injury, 610 Medicine & health, Diabetic nephropathy, QD415-436, Biochemistry, Glomerulonephritis, Sphingosine, QP1-981, Animals, Humans, Sphingosine Kinase, ddc:610, Wilms tumor, Kidney disease, Disease Models, Animal, Phosphotransferases (Alcohol Group Acceptor), Receptors, Lysosphingolipid, Kidney Tubules, Sphingosine 1-phosphate, Kidney Diseases, Lysophospholipids, ddc: ddc:610
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