Cardiovascular disease (CVD) is the most common cause of death in both sexes. There are sex and gender differences in the disease; that is, the epidemiology, pathophysiology, diagnostics, treatment response, and prognosis, as well as how women and men experience the disease in their sociocultural setting, may differ. CVD presents later in women, who are therefore older and more likely to suffer from comorbidities such as diabetes and hypertension. Women have smaller vessels, including the coronaries, and they also present more often with acute coronary syndrome including myocardial infarction with normal coronaries. Women do not always have the typical symptoms of myocardial infarction and therefore may seek help later. Prevention is as important in men as it is in women since 6 of 10 deaths due to CVD may be prevented. It is therefore very important that all health professionals as well as women themselves are aware of and know about CVD. The profess ion must also participate in disseminating knowledge about female CVD. This paper aims to get the reader to realize the importance of taking sex and gender into account when treating female or male patients with heart problems.