Polyethersulfone as base material has proven its suitability for synthetic dialysis membranes since more than one decade. Recently, a new generation of high-performance polyethersulfone membranes has been introduced, which are the result of an advanced spinning process. They are characterized by an improved permselectivity due to a more homogenous and dense pore size distribution. These innovative membranes achieve an outstanding middle molecule removal at low albumin loss and have best biocompatibility characteristics. Provided that the albumin permeability is low, the pyrogen retention capability is on a par with the best references. Overall, polyethersulfone high-performance membranes are highly efficient, biocompatible, safe and suited for all current dialysis procedures.