Biology of Kisspeptins
Biology of Kisspeptins
In recent years, a substantial body of evidence has accumulated suggesting that the hypothalamic peptide hormone kisspeptin and its cognate receptor, G-protein-coupled receptor 54, play a fundamental role both as gatekeepers for the initiation of puberty and in the regulation of the hypothalamic-pituitary-gonadal axis. This review discusses the physiology of the kisspeptin signalling system and examines how findings from animal and human studies have contributed to our understanding of the pathophysiology of idiopathic hypogonadotropic hypogonadism.
Male, Hypothalamo-Hypophyseal System, Kisspeptins, Hypogonadism, Placenta, Reproduction, Tumor Suppressor Proteins, Puberty, Macaca mulatta, Rats, Receptors, G-Protein-Coupled, Pregnancy, Animals, Humans, Female, Gonads, Receptors, Kisspeptin-1, Signal Transduction
Male, Hypothalamo-Hypophyseal System, Kisspeptins, Hypogonadism, Placenta, Reproduction, Tumor Suppressor Proteins, Puberty, Macaca mulatta, Rats, Receptors, G-Protein-Coupled, Pregnancy, Animals, Humans, Female, Gonads, Receptors, Kisspeptin-1, Signal Transduction
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