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Ophthalmic Research
Article . 1987 . Peer-reviewed
Data sources: Crossref
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Ophthalmic Research
Article . 1987
Data sources: Europe PubMed Central
https://dx.doi.org/10.1159/000...
Article
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Changes of Lens Crystallins Photosensitized with Tryptophan Metabolites

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1987 English Publisher:S. Karger AGJournal:Ophthalmic Research, volume 19, pages 157-163 (issn: 0030-3747, eissn: 1423-0259, Copyright policy )
Authors: H, Ichijima; S, Iwata;

doi: 10.1159/000265488

pmid: 3658326

Changes of Lens Crystallins Photosensitized with Tryptophan Metabolites

Abstract

The effect of UV irradiation on bovine lens soluble proteins (crystallins) in the presence of tryptophan metabolites was investigated in vitro. The cross-linking of crystallins by UV irradiation was accelerated by kynurenine, 3-hydroxykynurenine, anthranilic acid and 3-hydroxyanthranilic acid. On denaturation of crystallins by photooxidation, alpha-crystallin was characterized by the formation of water-soluble HMW (high molecular weight) protein, while water-insoluble HMW protein was produced from beta- and gamma-crystallin. These HMW aggregates showed cross-linking by non-disulfide covalent bonds. LMW (low molecular weight) peptides were formed by degradation of alpha- and beta-crystallin.

Related Organizations
Keywords

Radiation-Sensitizing Agents, Solubility, Ultraviolet Rays, Lens, Crystalline, Chromatography, Gel, Tryptophan, Animals, Cattle, Crystallins

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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Average
Average
Average
gold