Heterogeneity of Eosinophils in Chronic Eosinophilic Pneumonia
Copyright policy )Heterogeneity of Eosinophils in Chronic Eosinophilic Pneumonia
It has previously been shown that patients with chronic eosinophilic pneumonia can be divided into 2 groups according to the chemotactic response of their eosinophils to 5 different eosinophil chemotactic factors (ECFs) and laboratory findings. In contrast, eosinophils obtained by bronchoalveolar lavage from both groups responded to all 5 ECFs. The correlation between the two groups and the expression of several antigens (VLA-4, CD69, ICAM-1 and CD11b) on eosinophils. The VLA-4 expression of group 1 eosinophils was higher than that of group 2 eosinophils. More interestingly, eosinophils that migrated towards ECF-PI9 expressed less CD69 than those that migrated towards other STO-2-derived ECF. The heterogeneous response of eosinophils to STO-2-derived ECFs suggests that the population of eosinophils is heterogeneous.
- Kagawa University Japan
- Kumamoto University Japan
Antigens, Differentiation, T-Lymphocyte, Integrins, L-Lactate Dehydrogenase, Chemotactic Factors, Eosinophil, Receptors, Lymphocyte Homing, Macrophage-1 Antigen, Integrin alpha4beta1, Eosinophils, Chemotaxis, Leukocyte, Antigens, CD, Chronic Disease, Humans, Lectins, C-Type, Pulmonary Eosinophilia, Cell Adhesion Molecules
Antigens, Differentiation, T-Lymphocyte, Integrins, L-Lactate Dehydrogenase, Chemotactic Factors, Eosinophil, Receptors, Lymphocyte Homing, Macrophage-1 Antigen, Integrin alpha4beta1, Eosinophils, Chemotaxis, Leukocyte, Antigens, CD, Chronic Disease, Humans, Lectins, C-Type, Pulmonary Eosinophilia, Cell Adhesion Molecules
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