descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1989 English Publisher:S. Karger AGJournal:International Archives of Allergy and Immunology, volume 90, pages 43-46 (issn: 1018-2438, eissn: 1423-0097,

Authors: K, Banovac; L, Ghandur-Mnaymneh; J, Leone; D, Neylan; A, Rabinovitch;

doi: 10.1159/000234998

pmid: 2478484

Intrathyroidal Mast Cells Express Major Histocompatibility Complex Class-II Antigens

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Abstract

We studied the expression of major histocompatibility complex (MHC) class-II antigen in mast cells of rat thyroid glands. In the normal rat thyroid, mast cells express MHC class-II antigen. In BioBreeding Wistar (BB/W) rats, the strain of animals prone to develop spontaneous autoimmune thyroiditis, the number of MHC class-II-positive mast cells was significantly higher than in normal rats (p <0.01). Furthermore, intrathyroidal mast cells in BB/W rats showed an increased MHC class-II expression before the appearance of circulating thyroid antibodies or the infiltration of tissue with mononuclear cells. These data suggest that mast cells in the rat thyroid gland may have a function as antigen-presenting cells.

Related Organizations

Miami University
United States

Keywords

Staining and Labeling, Histocompatibility Antigens Class II, Thyroid Gland, Thyroiditis, Autoimmune, Rats, Inbred WF, Diabetes Mellitus, Experimental, Rats, Immunoenzyme Techniques, Species Specificity, Rats, Inbred Lew, Animals, Rats, Inbred BB, Mast Cells, Tolonium Chloride

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