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Response to 1-Deamino-8-D-Arginine Vasopressin in von Willebrand Disease

Name: Response to 1-Deamino-8-D-Arginine Vasopressin in von Willebrand Disease
Creator: Jeanne M. Lusher
Keywords: von Willebrand Diseases, 03 medical and health sciences, 0302 clinical medicine, Drug Administration Routes, Injections, Subcutaneous, Humans, Deamino Arginine Vasopressin, Drug Therapy, Combination, Tachyphylaxis, Administration, Intranasal

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994 English Publisher:S. Karger AGJournal:Pathophysiology of Haemostasis and Thrombosis, volume 24, pages 276-284 (issn: 1424-8832, eissn: 1424-8840,

Authors: Jeanne M. Lusher;

doi: 10.1159/000217114

pmid: 7843638

Response to 1-Deamino-8-D-Arginine Vasopressin in von Willebrand Disease

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Abstract

The synthetic agent, l-deamino-8-D-arginine vasopressin (DDAVP), is generally regarded to be the treatment of choice for persons with type I von Willebrand disease (vWD), and may be useful in type IIA vWD as well. Several formulations of the drug are available, including a highly concentrated intranasal spray formulation which is ideal for home use. The degree of F VIII and vWF response to DDAVP varies among individuals, but is generally consistent in individual patients over time. Some have tachyphylaxis while others do not. While side effects are uncommon, DDAVP is a potent antidiuretic agent. Thus one should be aware of the possibility of hyponatremia and water intoxication if certain precautions are not observed.

Related Organizations

Boston Children's Hospital
United States
Children's Hospital of Michigan
United States

Keywords

von Willebrand Diseases, Drug Administration Routes, Injections, Subcutaneous, Humans, Deamino Arginine Vasopressin, Drug Therapy, Combination, Tachyphylaxis, Administration, Intranasal, Antifibrinolytic Agents

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	35
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%