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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Pathophysiology of H...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Haemostasis
Article . 1974
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Hobby-Induced Factor VII Deficiency

Authors: A de Vries; J Kruglak; Isaac Cohen; Pinkhas J;

Hobby-Induced Factor VII Deficiency

Abstract

Hemorrhagíc tendency and granulocytopenia due to prolonged contact with trichloroethylene and toluene are described in a boy whose hobby was model air-plane assembly. The hemostatic defects found were hypoproconvertinemia, moderate hypofibrinogenemia, and increased capillary fragility. The clinical and laboratory abnormalities disappeared following interruption of the exposure. The abnormalities in the coagulation mechanism are ascribed to a toxic effect of the trichloroethylene on the liver, while the granulocytopenia is considered to reflect a bone marrow-depressing action of benzene contaminating the toluene. The increased capillary fragility is presumed to be due to a toxic effect of the chemicals on the blood vessels.

Keywords

Male, Capillary Fragility, Adolescent, Factor VII Deficiency, Humans, Hemorrhage, Leukopenia, Toluene, Trichloroethylene

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
gold
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