Advanced Glycation End Products of the Maillard Reaction and Their Relation to Aging

descriptionPublicationkeyboard_double_arrow_right Article 14 Apr 2009 English Publisher:S. Karger AGJournal:Gerontology (issn: 0304-324X, eissn: 1423-0003,

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Authors: S, Horiuchi; N, Araki;

doi: 10.1159/000213622

pmid: 7926861

Advanced Glycation End Products of the Maillard Reaction and Their Relation to Aging

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Abstract

Long-term incubation of proteins with glucose leads to advanced glycation end products (AGE). Demonstration of AGE in vivo as well as determination of its main structure are crucial to elucidate its potential link to aging processes and diabetic complications. We prepared polyclonal and monoclonal anti-AGE antibodies and used them to identify and quantitate AGE in human lens proteins. Results suggest that there occurs a common AGE structure and provide the direct evidence for the presence of AGE in human lens crystallins and its age-related increase.

Related Organizations

Niigata University
Japan
Kumamoto University
Japan

Keywords

Glycation End Products, Advanced, Aging, Immunoblotting, Lens, Crystalline, Humans, Enzyme-Linked Immunosorbent Assay, Maillard Reaction

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