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Ischemia in Aged Brain

Name: Ischemia in Aged Brain
Creator: Hoyer S
Keywords: Cerebral Cortex, Male, Aging, 03 medical and health sciences, Glucose, 0302 clinical medicine, 05 social sciences, Animals, Rats, Inbred Strains, 0501 psychology and cognitive sciences

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1987 English Publisher:S. Karger AGJournal:Gerontology, volume 33, pages 203-206 (issn: 0304-324X, eissn: 1423-0003,

Authors: Hoyer S;

doi: 10.1159/000212877

pmid: 3653703

Ischemia in Aged Brain

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Abstract

A 15-min complete cerebral ischemia, and repetitive ischemic insults of 15-min duration each cause changes in brain cortical glucose and energy metabolism which are similar in quality but different in quantity. Abnormalities in glycolytic flux, lactate production, cessation of oxidation and energy production were found to be more pronounced with advancing age, thus indicating a reduced biological plasticity of the brain to meet emergency conditions. Repeatedly occurring ischemic insults may damage energy metabolism in particular.

Related Organizations

Heidelberg University
Germany

Keywords

Cerebral Cortex, Male, Aging, Glucose, Animals, Rats, Inbred Strains, Energy Metabolism, Brain Ischemia, Rats

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	17
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average