Decreased Erythrocyte Deformability in Cholestatic Jaundice

descriptionPublicationkeyboard_double_arrow_right Article 05 Mar 2009 English Publisher:S. Karger AGJournal:Acta Haematologica (issn: 0001-5792, eissn: 1421-9662,

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Authors: H, Rogausch;

doi: 10.1159/000208577

pmid: 5001410

Decreased Erythrocyte Deformability in Cholestatic Jaundice

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Abstract

The anemia in experimental cholestatic jaundice has been studies in rabbits. A decreased erythrocyte deformability has been found in bile duct ligated animals and failed to be traceable in sham-operated ones. The deteriorated deformability of the red cells in a first step is caused by the action of surface active substances and secondly by other factors as a possibly deranged cell metabolism. Both factors will deteriorate the flexibility and thus the erythrocyte life-span.

Related Organizations

Philipps-University of Marburg
Germany

Keywords

Cholestasis, Erythrocytes, Cell Survival, Cell Membrane, Sodium, Osmotic Fragility, Surface-Active Agents, Hematocrit, Hemoglobinometry, Potassium, Animals, Bile, Rabbits

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