Megacolon in Rats

descriptionPublicationkeyboard_double_arrow_right Article 03 Feb 2009 English Publisher:S. Karger AGJournal:Digestion (issn: 0012-2823, eissn: 1421-9867,

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Authors: J S, Oliveira; M A, Llorach-Velludo; V N, Sales-Neto;

doi: 10.1159/000200239

pmid: 2373271

Megacolon in Rats

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Abstract

Four months of sigmoid colon intrinsic denervation of young male Wistar rats resulted in typical megacolon. Average 46.0% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in a 480-nm extension of the treated segment. Increased thickness of the megacolon wall was due to muscle hypertrophy (+117.4%) and mucosal hyperplasia (+53.9%) as shown by morphometry. The potential usefulness of this experimental model is emphasized.

Keywords

Male, Megacolon, Toxic, Colon, Sigmoid, Sympathectomy, Chemical, Animals, Myenteric Plexus, Colitis, Ulcerative, Rats, Inbred Strains, Benzalkonium Compounds, Rats

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