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Tissue Distribution of Primaquine in the Rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1981 English Publisher:S. Karger AGJournal:Pharmacology, volume 22, pages 330-336 (issn: 0031-7012, eissn: 1423-0313,

Authors: James B. Griffin; David J. Holbrook; Betsy R. Gibson; Linda Fowler;

doi: 10.1159/000137508

pmid: 7255540

Tissue Distribution of Primaquine in the Rat

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Abstract

The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver. At each interval, the concentrations of unmetabolized primaquine were (in order): lung greater than liver, kidney, spleen greater than heart greater than brain greater than or equal to blood. At 3 h after the injection of [6-O-methyl-3H]primaquine, unmetabolized primaquine constituted 10% of the total 3H in blood and 40-60% of the total 3H in liver, brain, heart and kidney.

Related Organizations

University of North Carolina at Chapel Hill
United States
University of North Carolina System
United States

Keywords

Male, Kinetics, Animals, Tissue Distribution, Primaquine, Tritium, Half-Life, Rats

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