Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene
Copyright policy )Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene
Many subgroups of the RAB gene, a member of the RAS superfamily have been identified. Here we report the isolation and analysis of a cDNA encoding a putative small GTP-binding protein, designated RABL, from a human fetal lung cDNA library. RABL encodes 216 amino acids that are 86 % identical to members of the RAB5 subfamily and it shows 94% homology in nucleotide sequence with RAB5C of dog. This gene was expressed ubiquitously in all human tissues examined. By fluorescence in situ hybridization we mapped RABL to chromosome band 17q21.2.
DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Dogs, Genes, Species Specificity, GTP-Binding Proteins, Multigene Family, Animals, Humans, Amino Acid Sequence, Sequence Alignment, In Situ Hybridization, Fluorescence, Chromosomes, Human, Pair 17, Gene Library, rab5 GTP-Binding Proteins
DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Dogs, Genes, Species Specificity, GTP-Binding Proteins, Multigene Family, Animals, Humans, Amino Acid Sequence, Sequence Alignment, In Situ Hybridization, Fluorescence, Chromosomes, Human, Pair 17, Gene Library, rab5 GTP-Binding Proteins
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