Cell surface antigens
Copyright policy )Cell surface antigens
A stable human-Chinese hamster ovary cell hybrid has been produced which, in addition to the complement of Chinese hamster ovary (CHO-K1) chromosomes, contains only one human chromosome, No. 11. The human cell-surface antigens whose expression is controlled by human chromosome 11, and are expressed by this hybrid, have been defined as the A<sub>L</sub> immunogenetic complex. Although one component of this immunogenetic complex (a<sub>1</sub>) is also expressed by human red blood cells, a second component (a<sub>2</sub>) is not. Killing of an aι+ hybrid by anti-a<sub>1</sub> serum and complement can be completely inhibited by glycophorin, the major glycoprotein component of the human erythrocyte membrane. In the presence of complement, antiserum prepared against glycophorin will kill only those cells which express a<sub>1</sub>. The anti-a<sub>1</sub> killing activity of the anti-glycophorin can be adsorbed out only by those cells which express ai. Therefore, it is concluded that the ai cell-surface antigen has at least one antigenic component in common with glycophorin.
- University of Colorado System United States
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).13 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!