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Modulation of macrophages by infectious bursal disease virus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 English Publisher:S. Karger AGJournal:Cytogenetic and Genome Research, volume 117, pages 388-393 (issn: 1424-8581, eissn: 1424-859X,

Authors: Mahesh Khatri; Jagdev M. Sharma;

doi: 10.1159/000103202

pmid: 17675882

Modulation of macrophages by infectious bursal disease virus

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Abstract

Infectious bursal disease is one of the most important naturally occurring viral diseases of chickens worldwide. The causative agent, infectious bursal disease virus (IBDV), belongs to the family Birnaviridae. This viruscauses an acute, highly contagious and immunosuppressive disease in chickens. The virus infects and destroys actively dividing IgM-bearing B cells. Although B cells are the principal targets for IBDV, recent data show that the virus also infects macrophages. IBDV-infected macrophages produce various cytokines and chemokines which may play an important role in the protection and/or pathogenesis of IBDV. In this review, the modulatory effects of IBDV on macrophages will be discussed.

Related Organizations

University of Minnesota Morris
United States

Keywords

Phagocytosis, Macrophages, Animals, Cytokines, Humans, Disease Susceptibility, Birnaviridae Infections, Infectious bursal disease virus

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	14
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