Defining Insulin-Like Growth Factor-I Deficiency
Copyright policy )Defining Insulin-Like Growth Factor-I Deficiency
• The GH-IGF system should be viewed like other endocrine systems, with a central, trophic hormone (GH) and a peripherally active hormone (IGF-I). • A decrease in IGF-I production, without a concomitant impairment in GH secretion, should be termed 'Primary IGF deficiency'. • IGF-I and IGFBP-3 measurements should be given precedence in the work-up of children with suspected defects of the GH-IGF axis. • The terms 'GH insensitivity' and 'IGF-I deficiency' are not identical terms. To define a disease condition in terms of its lack of response to treatment is conceptually misleading.
- University of Tübingen Germany
- Universitätskinderklinik Germany
Insulin-Like Growth Factor Binding Protein 3, Growth Hormone, Animals, Humans, Endocrine System, Insulin-Like Growth Factor I, Growth Disorders
Insulin-Like Growth Factor Binding Protein 3, Growth Hormone, Animals, Humans, Endocrine System, Insulin-Like Growth Factor I, Growth Disorders
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