The Structural Perspective on CDK5
Copyright policy )The Structural Perspective on CDK5
Cyclin-dependent kinase 5 (CDK5) plays an essential role in the development of the central nervous system during mammalian embryogenesis. In the adult, CDK5 is required for the maintenance of neuronal architecture. Its deregulation has profound cytotoxic effects and has been implicated in the development of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. In this review, we concentrate on the regulation of CDK5 activity, privileging a structural perspective based on a decade of structural analyses of different members of the CDK family, including CDK2 and CDK5. We review the activation mechanism of CDK5 and discuss its differences and similarities with that of CDK2 and of the other members of the CDK family.
- National Institute for Nuclear Physics Italy
- Max Planck Society Germany
- European Institute of Oncology Italy
Aurora Universities Network, Models, Molecular, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 5, Nerve Tissue Proteins, Cyclin-Dependent Kinases, Enzyme Activation, Cellular and Molecular Neuroscience, Structure-Activity Relationship, Developmental Neuroscience, Neurology, CDC2-CDC28 Kinases, Animals, Biologie, Protein Binding
Aurora Universities Network, Models, Molecular, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 5, Nerve Tissue Proteins, Cyclin-Dependent Kinases, Enzyme Activation, Cellular and Molecular Neuroscience, Structure-Activity Relationship, Developmental Neuroscience, Neurology, CDC2-CDC28 Kinases, Animals, Biologie, Protein Binding
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