Antituberculous Activity of Norfloxacin Mannich Bases with Isatin Derivatives

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2001 English Publisher:S. Karger AGJournal:Chemotherapy, volume 47, pages 266-269 (issn: 0009-3157, eissn: 1421-9794,

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Authors: S N, Pandeya; D, Sriram; P, Yogeeswari; S, Ananthan;

doi: 10.1159/000048533

pmid: 11399863

Antituberculous Activity of Norfloxacin Mannich Bases with Isatin Derivatives

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Abstract

Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The compounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv at 12.5 µg/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower than 6.25 µg/ml.

Related Organizations

Southern Research Institute
United States
Banaras Hindu University
India
National Institutes of Health
United States
National Institute of Allergy and Infectious Diseases
United States

Keywords

Isatin, Mannich Bases, Anti-Infective Agents, Antitubercular Agents, Drug Evaluation, Preclinical, Mycobacterium tuberculosis, Norfloxacin

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