DNA Vaccines

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1999 English Publisher:S. Karger AGJournal:Intervirology, volume 42, pages 117-124 (issn: 0300-5526, eissn: 1423-0100,

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Authors: J, Encke; J, zu Putlitz; J R, Wands;

doi: 10.1159/000024971

pmid: 10516466

DNA Vaccines

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Abstract

Chronic infections with hepatitis B (HBV) and hepatitis C (HCV) virus are worldwide problems often leading to the development of chronic liver disease and hepatocellular carcinoma. Genetic immunizations with DNA encoding for structural and nonstructural proteins of HCV and HBV in experimental mice generate a broad base CD4+ and CD8+ cellular immune response which may be required for viral clearance from the host. DNA based immunization is a promising antiviral approach for the development of therapeutic and prophylactic vaccine against HBV and HCV.

Related Organizations

Heidelberg University
Germany
Harvard University
United States
Brown University
United States

Keywords

Mice, T-Lymphocytes, Antibody Formation, Vaccines, DNA, Animals, Humans, Hepatitis B Vaccines, Immunization, Viral Vaccines, Hepacivirus

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