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Cancer Discovery

Article . 2022 . Peer-reviewed

Data sources: Crossref

Cancer Discovery

Article . 2022

Data sources: Europe PubMed Central

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ctDNA: Moving toward Clinical Utility

descriptionPublicationkeyboard_double_arrow_right Article 07 Jun 2022 English Publisher:American Association for Cancer Research (AACR)Journal:Cancer Discovery, volume 12, pages OF4-OF4 (issn: 2159-8274, eissn: 2159-8290,

doi: 10.1158/2159-8290.cd-nd2022-0008

pmid: 35671334

ctDNA: Moving toward Clinical Utility

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Abstract

Abstract Findings from the phase II DYNAMIC study suggest that circulating tumor DNA analyses could help clinicians decide whether patients with stage II colon cancer require chemotherapy after standard surgery. Liquid biopsies could also shed light on the development of resistance to KRASG12C inhibition, paving the way for better treatment strategies.

Keywords

Proto-Oncogene Proteins p21(ras), Drug Resistance, Neoplasm, Colonic Neoplasms, Mutation, Biomarkers, Tumor, Liquid Biopsy, Humans, Circulating Tumor DNA

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