CD4+ T-cell Depletion Prevents GVHD

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Cancer Discovery

Article . 2017 . Peer-reviewed

Data sources: Crossref

Cancer Discovery

Article . 2018

Data sources: Europe PubMed Central

CD4+ T-cell Depletion Prevents GVHD

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2017 English Publisher:American Association for Cancer Research (AACR)Journal:Cancer Discovery, volume 7, pages OF3-OF3 (issn: 2159-8274, eissn: 2159-8290,

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doi: 10.1158/2159-8290.cd-nb2017-063

pmid: 28450427

CD4+ T-cell Depletion Prevents GVHD

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Abstract

Abstract Temporary removal of CD4+ T cells after an allogeneic hematopoietic stem-cell transplant leads to changes in the nature of CD8+ T cells that, according to a mouse study, help prevent graft-versus-host disease without jeopardizing the therapy's potential to eliminate leukemia or lymphoma.

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