Two Faces of SIVA
Copyright policy )Two Faces of SIVA
Abstract Summary: In non–small cell lung cancer cells that contain a mutated KRAS gene, SIVA, a p53 target gene that is critical for apoptosis, is overexpressed in a p53-independent manner and promotes tumorigenesis through the stimulation of mTOR signaling. The ablation of Siva in conditional knockout mice results in an inhibition of tumor development that makes SIVA an interesting new candidate therapeutic target for the treatment of a carcinoma with few therapeutic options. Cancer Discov; 5(6); 581–3. ©2015 AACR. See related article by Van Nostrand and colleagues, p. 622.
- Icahn School of Medicine at Mount Sinai United States
Gene Expression Regulation, Neoplastic, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Animals, Humans, Female, Tumor Suppressor Protein p53, Apoptosis Regulatory Proteins
Gene Expression Regulation, Neoplastic, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Animals, Humans, Female, Tumor Suppressor Protein p53, Apoptosis Regulatory Proteins
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