Favoritism in DNA Methylation
Copyright policy )Favoritism in DNA Methylation
Abstract This perspective on Candiloro and Dobrovic (beginning on p. 862 in this issue of the journal) highlights the interplay between epigenetic aberrations and underlying DNA sequence changes and illustrates how these alterations may predispose individuals to cancer. Candiloro and Dobrovic clearly show that particular genotypes of the MGMT gene are associated with its methylation in healthy individuals. Aberrant MGMT methylation may identify individuals who could be targeted for cancer screening and chemoprevention strategies.
- University of Queensland Australia
- University of Queensland Australia
- UNSW Sydney Australia
Psychiatry, Tumor Suppressor Proteins, DNA Methylation, DNA Repair Enzymes, Neoplasms, Animals, Humans, 1306 Cancer Research, 2730 Oncology, Genetic Predisposition to Disease, DNA Modification Methylases
Psychiatry, Tumor Suppressor Proteins, DNA Methylation, DNA Repair Enzymes, Neoplasms, Animals, Humans, 1306 Cancer Research, 2730 Oncology, Genetic Predisposition to Disease, DNA Modification Methylases
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