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Human Leukocyte Antigen–G and Cancer Immunoediting

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Feb 2008Embargo end date: 01 Jan 2008 Switzerland English Publisher:American Association for Cancer Research (AACR)Journal:Cancer Research, volume 68, pages 627-630 (issn: 0008-5472, eissn: 1538-7445,

Authors: Urosevic, M; Dummer, R;

doi: 10.1158/0008-5472.can-07-2704 , 10.5167/uzh-13927

pmid: 18245459

Human Leukocyte Antigen–G and Cancer Immunoediting

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Abstract

Abstract Immunosurveillance is an extrinsic mechanism of cancer suppression that eliminates nascent tumors. However, the selection imposed by immunosurveillance can drive tumor evolution and the emergence of clinically apparent neoplasms. Mechanisms of immune escape acquired by less immunogenic variants during this process, termed immunoediting, may contribute significantly to malignant progression. In this review, we summarize the evidence that up-regulation of the nonclassic human leukocyte antigen (HLA) class I molecule HLA-G in tumor cells plays an important role in cancer and immune escape. [Cancer Res 2008;68(3):627–30]

Country

Switzerland

Related Organizations

Prairie View A&M University
United States
University Hospital of Zurich
Switzerland
University of Zurich
Switzerland

Keywords

HLA-G Antigens, HLA Antigens, Monitoring, Immunologic, Neoplasms, Histocompatibility Antigens Class I, 10177 Dermatology Clinic, Humans, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	80
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%