Title: Chronic recurrent multifocal osteomyelitis Chronic recurrent multifocal osteomyelitis is currently considered a variant of a rare autoinflammatory disorder, which requires a high index of clinic suspicion for suitable diagnostic and therapeutic approach. We present a typical case, providing data on etiopathogenetic hypothesis currently handled in this entity.. The early detection of these malformations can prevent the appearance of chronic lung diseases and can allow for the best therapeutic approach. Although most of the cases do not require treatment, some of them require specific and more aggressive handling.